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Synthesis
DOI: 10.1055/a-2618-0514
paper

Total Synthesis of Isatisindigoticanine H

Krishna R Wabale
1   Organic Chemistry, CSIR - National Chemical Laboratory, Pune, India (Ringgold ID: RIN29616)
,
Chepuri Venkata Ramana 
2   ORGANIC CHEMISTRY, CSIR - NATIONAL CHEMICAL LABORATORY, Pune, India
› InstitutsangabenGefördert durch: UGC
Gefördert durch: CSIR
Gefördert durch: SERB CRG/2021/005729
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The first total synthesis of the naturally occurring Isatisindigoticanine H has been completed by employing D-mannitol as the chiral pool precursor to install the requisite stereochemistry of the natural product. Construction of the thiazole unit by dehydrative cyclization of a -halo ketone with thiourea followed by the Sandmeyer’s reaction and subsequent nucleophilic addition of lithiated bromothiazole to the Weinreb amide are the key reactions employed in this regard.



Publikationsverlauf

Eingereicht: 04. April 2025

Angenommen nach Revision: 21. Mai 2025

Accepted Manuscript online:
21. Mai 2025

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