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DOI: 10.1055/a-2618-0514
Total Synthesis of Isatisindigoticanine H
Gefördert durch: UGC
Gefördert durch: CSIR
Gefördert durch: SERB CRG/2021/005729
Funding Information We thank SERB (CRG/2021/005729) for funding this project and CSIR-UGC for a fellowship to KRW.
Abstract
The first total synthesis of the naturally occurring isatisindigoticanine H has been completed by employing D-mannitol as the chiral pool precursor to install the requisite stereochemistry of the natural product. Construction of the thiazole unit by dehydrative cyclization of a α-halo ketone with thiourea followed by Sandmeyer’s reaction and subsequent nucleophilic addition of lithiated bromothiazole to the Weinreb amide are the key reactions employed in this regard.
Keywords
Total synthesis - Isatisindigoticanine H - Chiral pool approach - Indothiazinone - Sandmeyer reactionPublikationsverlauf
Eingereicht: 04. April 2025
Angenommen nach Revision: 21. Mai 2025
Accepted Manuscript online:
21. Mai 2025
Artikel online veröffentlicht:
25. Juli 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
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