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Synlett
DOI: 10.1055/a-2608-2142
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Electrochemical Synthesis of Ketones via Metal-Free Decarboxylative Coupling of Vinyl Azides and NHPI Esters

Bhawana Jat
1   Chemistry, Mohanlal Sukhadia University Department of Chemistry, Udaipur, India (Ringgold ID: RIN564433)
,
Himagni Verma
1   Chemistry, Mohanlal Sukhadia University Department of Chemistry, Udaipur, India (Ringgold ID: RIN564433)
,
Satpal Singh Badsara 
2   Department of Chemistry, Banaras Hindu University, Varanasi, India (Ringgold ID: RIN30114)
,
Siddharth Sharma
1   Chemistry, Mohanlal Sukhadia University Department of Chemistry, Udaipur, India (Ringgold ID: RIN564433)
› Author AffiliationsSupported by: Science and Engineering Research Board CRG/2023/00713
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We introduce a metal-free method for C–C bond formation by coupling NHPI esters with vinyl azides through electrochemical synthesis. By converting carboxylic acids into radical-initiating NHPI esters, our approach achieves efficient C(sp³)–C(sp³) bond formation without needing metal catalysts. This method is highly adaptable, enabling the coupling of various NHPI esters with a broad range of vinyl azides, including those with halide or heteroatom substitutions.



Publication History

Received: 23 March 2025

Accepted after revision: 14 May 2025

Accepted Manuscript online:
14 May 2025

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