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DOI: 10.1055/a-2605-1414
letter

Nickel-catalyzed Enantioselective Hydroboration of Styrenes

Yue-Gang Chen 
1   Chemical Engineering and Technology, Tianjin University, Tianjin, China (Ringgold ID: RIN12605)
2   School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, China (Ringgold ID: RIN12646)
3   Zhejiang Sci-Tech University Shengzhou Innovation Research Institute, Zhejiang Sci-Tech University Shengzhou Innovation Research Institute, Shengzhou, China
,
Chunpeng Yang
4   School of Chemical Engineering and Technology, Tianjin University, Tianjin, China (Ringgold ID: RIN12605)
› Author AffiliationsSupported by: Fundamental Research Funds of Zhejiang Sci-Tech University 23062110-Y, 22062143-Y
Supported by: Zhejiang Province Post-Doctoral Research Project Selected Funding ZJ2023033
Supported by: China Postdoctoral Science Foundation 2024M762339
Supported by: Natural Science Foundation of Zhejiang Province LQ23B020009
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Herein, we established a Ni-catalyzed enantioselective hydroboration process of styrene derivatives utilizing a chiral Box ligand with B2pin2 as the hydroboration reagent. This approach demonstrates the feasibility of a stereoselective transmetalation of a benzylic carbon–nickel bond using B2pin2. The sought-after stable borated product can be achieved with elevated regio- and enantioselectivity under mild circumstances.



Publication History

Received: 09 March 2025

Accepted after revision: 09 May 2025

Accepted Manuscript online:
09 May 2025

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