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DOI: 10.1055/a-2602-4660
DOI: 10.1055/a-2602-4660
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Small Molecules in Medicinal Chemistry
A Tale of Drug Discovery: Synthesis, Bioassay, and Computational Docking Studies of Novel Curcuminoids
Abstract
With the goal to overcome the bio-physicochemical drawbacks of parent curcumin (CUR) and to develop analogues with improved biological profiles and higher potencies, the present account provides a review summary of the work in my laboratory on the synthesis of structurally diverse libraries of curcuminoids (CURs), their in vitro bioassays, and computational docking studies. These efforts resulted in the discovery of a subset of compounds with exceptional antiproliferative and apoptotic activity that warrant further investigation.
1 Introduction
2 Synthetic Strategies
3 Bioassay Studies
4 Computational Docking Studies
5 Summary and Outlook
Key words
novel curcuminoids - synthesis - in vitro bioassay - anticancer activity - computational dockingPublication History
Received: 10 March 2025
Accepted after revision: 07 May 2025
Accepted Manuscript online:
07 May 2025
Article published online:
09 July 2025
© 2025. Thieme. All rights reserved
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