Abstract
We introduce an innovative methodology for synthesizing hydantoins from amino acids
using readily available carbodiimides, emphasizing the crucial role of temperature
in the reaction process. This approach presents significant advantages over conventional
methods involving isocyanates, facilitating easier handling and minimizing associated
risks. Our strategy not only allows for the efficient production of a diverse array
of hydantoin derivatives but also adheres to environmentally sustainable practices.
The optimized reaction conditions enhance efficiency, marking a significant advancement
in the field of organic synthesis. This method presents significant advantages for
industrial applications, as it is a heat-mediated process that does not require the
use of any bases or catalysts. By eliminating the need for additional reagents, this
approach simplifies the reaction conditions, reduces potential side reactions, and
minimizes the overall environmental impact. Additionally, the absence of catalysts
streamlines the purification process, making it more cost-effective and efficient
for large-scale production.
Key word
hydantoin - carbodiimide - amino acid - urea - N-heterocyclic organic compound
