Synthesis of Fluorinated 4-Aminopyrimidines via Brønsted Acid Mediated [2+2+2] Cycloaddition of β-Trifluoromethyl-1,3-enynamides with Nitriles

Synthesis 2025; 57(07): 1339-1345
DOI: 10.1055/a-2504-3203

paper

Qin Zeng

^aThe Public Experiment Center, University of Shanghai for Science and Technology, 516. Jungong Road, Shanghai 200093, P. R. China

,

Jintong Li

^bDepartment of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China

,

Yuanjing Xiao∗

^bDepartment of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China

Brønsted acid mediated [2+2+2] cycloaddition of β-CF₃-1,3-enynamides with nitriles affording fluorinated 4-aminopyrimidines was developed.

β-trifluoromethyl-enynamides - enynamides - pyrimidine - cycloaddition - Brønsted acid - nitrile

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12 CCDC 2382229 (3aa) contains the supplementary crystallographic data for this paper. The data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/structures . See also the Supporting Information.