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Synlett 2025; 36(01): 65-68
DOI: 10.1055/a-2310-0880
DOI: 10.1055/a-2310-0880
letter
Ligand-Promoted Palladium-Catalyzed β-C(sp3)–H Arylation of Ketones Using Acetohydrazide as a Transient Directing Group
This work was supported by the National Natural Science Foundation of China (NSFC) (Grant No. 21772092).
Abstract
A palladium-catalyzed β-C(sp3)–H arylation of aliphatic ketones by using acetohydrazide as a transient directing group has been developed. The reaction proceeds through a less-favored [5,5]-bicyclic palladacycle intermediate and is promoted by a pyridine ligand.
Key word
C–H arylation - transient directing group - acetohydrazides - ketones - palladium catalysis - pyridinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2310-0880.
- Supporting Information
Publikationsverlauf
Eingereicht: 05. April 2024
Angenommen nach Revision: 20. April 2024
Accepted Manuscript online:
20. April 2024
Artikel online veröffentlicht:
29. April 2024
© 2024. Thieme. All rights reserved
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