Synlett 2025; 36(01): 65-68
DOI: 10.1055/a-2310-0880
letter

Ligand-Promoted Palladium-Catalyzed β-C(sp3)–H Arylation of Ketones Using Acetohydrazide as a Transient Directing Group

Kai Jia
,
Junjie Wang
,
Xuan Wang
,
Chao Jiang
This work was supported by the National Natural Science Foundation of China (NSFC) (Grant No. 21772092).


Abstract

A palladium-catalyzed β-C(sp3)–H arylation of aliphatic ketones by using acetohydrazide as a transient directing group has been developed. The reaction proceeds through a less-favored [5,5]-bicyclic palladacycle intermediate and is promoted by a pyridine ligand.

Supporting Information



Publication History

Received: 05 April 2024

Accepted after revision: 20 April 2024

Accepted Manuscript online:
20 April 2024

Article published online:
29 April 2024

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