A Convenient Method for Synthesizing 1-Alkyl-2-acyl-sn-glycero-3-phosphoethanolamines

Dedicated to Professor Koichi Narasaka in celebration of his 80^th birthday (Sanju)

Abstract

A convenient method for synthesizing 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamines (1-alkyl-2-acyl-GPEs) starting from an optical active alcohol is described. In this method, the phosphate group was introduced through the transesterification that we developed, and a protected 1-alkyl-2-lyso-GPE was employed as an intermediate. This compound is stable and serves as a common intermediate for the synthesis of various 1-alkyl-2-acyl-GPEs with different acyl groups.

Key words

ether phospholipids - glycerophospholipids - phosphoethanolamines - transesterification - phosphorylation

Publikationsverlauf

Eingereicht: 26. Dezember 2023

Angenommen nach Revision: 30. Januar 2024

Accepted Manuscript online:
30. Januar 2024

Artikel online veröffentlicht:
20. Februar 2024

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