Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023

Abstract

This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.

Keywords

xenotransplantation - preclinical - clinical - cardiac

List of Participants

Abteilung für Herzchirurgie, Kerckhoff-Klinik GmbH Bad Nauheim -

Prof. Dr. Yeong-Hoon Choi

Dr. Nemanja Zukic

Klinik für Thorax- und kardiovaskuläre Chirurgie, Herz und Diabeteszentrum Bad Oeynhausen

Prof. Dr. Jan Gummert

Prof. Dr. René Schramm

Deutsches Herzzentrum der Charité Berlin

Prof. Dr. Christoph Knosalla

Freie Universität Berlin

Dr. Joachim Denner

Herzzentrum Dresden

Dr. Stefan Brose

Prof. Dr. Sems Malte Tugtekin

Pascal Tugtekin

Klinik für Herzchirurgie, Universitätsklinikum Düsseldorf

Prof. Dr. Artur Lichtenberg

Prof. Dr. Udo Boeken

Herzchirurgische Klinik, Uniklinikum Erlangen

Prof. Dr. Christian Heim

Kinderherzchirurgische Abteilung, Uniklinikum Erlangen

Prof. Dr. Oliver Dewald

Dr. Ariawan Purbojo

Klinik für Thorax- und kardiovaskuläre Chirurgie, Universitätsmedizin Essen

Prof. Dr. Arjang Ruhparwar (seit 01.04.2023 Klinik für Herz-, Thorax-, Transplantationschirurgie, Medizinische Hochschule Hannover)

PD Dr. Bastian Schmack (seit 01.04.2023 Klinik für Herz-, Thorax-, Transplantationschirurgie, Medizinische Hochschule Hannover)

Universitäts-Herzzentrum Freiburg/Bad Krozingen

Prof. Dr. Martin Czerny

PD Dr. David Schibilsky

Klinik für Herz-, Thorax- und Gefäßchirurgie, Universitätsmedizin Göttingen

Prof. Dr. Ingo Kutschka

Klinik für Herz- und Gefäßchirurgie, Universitätsklinikum Hamburg-Eppendorf

Prof. Dr. Hermann Reichenspurner

PD Dr. Alexander Bernhard

Klinik und Poliklinik für Kinderherzmedizin und EMAH, Universitätsklinikum Hamburg-Eppendorf

Prof. Dr. Michael Hübler

Dr. Samira Hübler

Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover

Prof. Dr. Axel Haverich

Dr. Tobias Goecke

Klinik für Herzchirurgie, Universitätsklinikum Heidelberg

PD Dr. Rawa Arif

Klinik für Herz- und Thoraxchirurgie, Universitätsklinikum Jena

Prof. Dr. Torsten Doenst

PD Dr. Gloria Färber

Klinik für Herz- und Gefäßchirurgie, Universitätsklinikum Schleswig-Holstein, Campus Kiel

Prof. Dr. Jochen Cremer

Prof. Dr. Assad Haneya

Paul-Ehrlich Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Langen

Prof. Dr. Ralf Reinhard Tönjes

Herzzentrum Leipzig

Dr. Uwe Schulz

Klinikum der Universität München

Prof. Dr. Christian Hagl

Prof. Dr. Michael Schmoeckel

Prof. Dr. Bruno Reichart

PD Dr. Matthias Längin

PD Dr. Jan-Michael Abicht

Dr. Michael Bender

Prof. Dr. Paolo Brenner

Dr. Carola Grinninger

Dr. Christine-Elena Kamla

Prof. Dr. Georg Marckmann

Prof. Dr. Sebastian Michel

Dr. Daniel Reichart

Reinhard Ellgass

Genzentrum und Centre for Innovative Medical Models (CiMM) der LMU München

Prof. Dr. Eckhard Wolf

Prof. Dr. Elisabeth Kempter

Dr. Barbara Keßler

Granzer Regulatory Consulting & Services, München

Dr. Stefan Blesse

Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg

Prof. Dr. Christof Schmid

PD Dr. Simon Schopka

Publikationsverlauf

Eingereicht: 25. September 2023

Angenommen: 22. November 2023

Accepted Manuscript online:
28. Dezember 2023

Artikel online veröffentlicht:
12. Februar 2024

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