CC BY-NC-ND 4.0 · Thorac Cardiovasc Surg 2024; 72(04): 273-284
DOI: 10.1055/a-2235-8854
Review Article

Current Status of Cardiac Xenotransplantation: Report of a Workshop of the German Heart Transplant Centers, Martinsried, March 3, 2023

Michael Schmoeckel
1   Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany
,
Matthias Längin
2   Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
,
Bruno Reichart
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
,
Jan-Michael Abicht
2   Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
,
Martin Bender
2   Klinik für Anaesthesiologie, LMU Klinikum, LMU München, Germany
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
,
Sebastian Michel
1   Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
,
Christine-Elena Kamla
1   Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany
,
Joachim Denner
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
4   Institut für Virologie, Fachbereich für Veterinärmedizin, Freie Universität Berlin, Berlin, Germany
,
Ralf Reinhard Tönjes
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
5   Paul-Ehrlich-Institut, Langen, Germany
,
Reinhard Schwinzer
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
6   Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Medizinische Hochschule Hannover, Hannover, Germany
,
Georg Marckmann
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
7   Institut für Ethik, Geschichte und Theorie der Medizin, LMU München, Germany
,
Eckhard Wolf
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
8   Lehrstuhl für Molekulare Tierzucht und Biotechnologie, Genzentrum der LMU München, Germany
,
Paolo Brenner
1   Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany
3   DFG-Transregio-Sonderforschungsbereich TR127—Xenotransplantation, Walter-Brendel-Zentrum für Experimentelle Medizin, LMU München, Germany
,
Christian Hagl
1   Herzchirurgische Klinik und Poliklinik, LMU Klinikum, LMU München, Germany
9   DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung e.V.), Partner Site Munich, Germany
› Author Affiliations

Abstract

This report comprises the contents of the presentations and following discussions of a workshop of the German Heart Transplant Centers in Martinsried, Germany on cardiac xenotransplantation. The production and current availability of genetically modified donor pigs, preservation techniques during organ harvesting, and immunosuppressive regimens in the recipient are described. Selection criteria for suitable patients and possible solutions to the problem of overgrowth of the xenotransplant are discussed. Obviously microbiological safety for the recipient and close contacts is essential, and ethical considerations to gain public acceptance for clinical applications are addressed. The first clinical trial will be regulated and supervised by the Paul-Ehrlich-Institute as the National Competent Authority for Germany, and the German Heart Transplant Centers agreed to cooperatively select the first patients for cardiac xenotransplantation.

List of Participants

Abteilung für Herzchirurgie, Kerckhoff-Klinik GmbH Bad Nauheim -


Prof. Dr. Yeong-Hoon Choi


Dr. Nemanja Zukic


Klinik für Thorax- und kardiovaskuläre Chirurgie, Herz und Diabeteszentrum Bad Oeynhausen


Prof. Dr. Jan Gummert


Prof. Dr. René Schramm


Deutsches Herzzentrum der Charité Berlin


Prof. Dr. Christoph Knosalla


Freie Universität Berlin


Dr. Joachim Denner


Herzzentrum Dresden


Dr. Stefan Brose


Prof. Dr. Sems Malte Tugtekin


Pascal Tugtekin


Klinik für Herzchirurgie, Universitätsklinikum Düsseldorf


Prof. Dr. Artur Lichtenberg


Prof. Dr. Udo Boeken


Herzchirurgische Klinik, Uniklinikum Erlangen


Prof. Dr. Christian Heim


Kinderherzchirurgische Abteilung, Uniklinikum Erlangen


Prof. Dr. Oliver Dewald


Dr. Ariawan Purbojo


Klinik für Thorax- und kardiovaskuläre Chirurgie, Universitätsmedizin Essen


Prof. Dr. Arjang Ruhparwar (seit 01.04.2023 Klinik für Herz-, Thorax-, Transplantationschirurgie, Medizinische Hochschule Hannover)


PD Dr. Bastian Schmack (seit 01.04.2023 Klinik für Herz-, Thorax-, Transplantationschirurgie, Medizinische Hochschule Hannover)


Universitäts-Herzzentrum Freiburg/Bad Krozingen


Prof. Dr. Martin Czerny


PD Dr. David Schibilsky


Klinik für Herz-, Thorax- und Gefäßchirurgie, Universitätsmedizin Göttingen


Prof. Dr. Ingo Kutschka


Klinik für Herz- und Gefäßchirurgie, Universitätsklinikum Hamburg-Eppendorf


Prof. Dr. Hermann Reichenspurner


PD Dr. Alexander Bernhard


Klinik und Poliklinik für Kinderherzmedizin und EMAH, Universitätsklinikum Hamburg-Eppendorf


Prof. Dr. Michael Hübler


Dr. Samira Hübler


Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover


Prof. Dr. Axel Haverich


Dr. Tobias Goecke


Klinik für Herzchirurgie, Universitätsklinikum Heidelberg


PD Dr. Rawa Arif


Klinik für Herz- und Thoraxchirurgie, Universitätsklinikum Jena


Prof. Dr. Torsten Doenst


PD Dr. Gloria Färber


Klinik für Herz- und Gefäßchirurgie, Universitätsklinikum Schleswig-Holstein, Campus Kiel


Prof. Dr. Jochen Cremer


Prof. Dr. Assad Haneya


Paul-Ehrlich Institut, Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Langen


Prof. Dr. Ralf Reinhard Tönjes


Herzzentrum Leipzig


Dr. Uwe Schulz


Klinikum der Universität München


Prof. Dr. Christian Hagl


Prof. Dr. Michael Schmoeckel


Prof. Dr. Bruno Reichart


PD Dr. Matthias Längin


PD Dr. Jan-Michael Abicht


Dr. Michael Bender


Prof. Dr. Paolo Brenner


Dr. Carola Grinninger


Dr. Christine-Elena Kamla


Prof. Dr. Georg Marckmann


Prof. Dr. Sebastian Michel


Dr. Daniel Reichart


Reinhard Ellgass


Genzentrum und Centre for Innovative Medical Models (CiMM) der LMU München


Prof. Dr. Eckhard Wolf


Prof. Dr. Elisabeth Kempter


Dr. Barbara Keßler


Granzer Regulatory Consulting & Services, München


Dr. Stefan Blesse


Klinik und Poliklinik für Herz-, Thorax- und herznahe Gefäßchirurgie, Universitätsklinikum Regensburg


Prof. Dr. Christof Schmid


PD Dr. Simon Schopka




Publication History

Received: 25 September 2023

Accepted: 22 November 2023

Accepted Manuscript online:
28 December 2023

Article published online:
12 February 2024

© 2024. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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