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Synthesis 2024; 56(03): 418-426
DOI: 10.1055/a-2201-9951
DOI: 10.1055/a-2201-9951
paper
Synthesis of Piperazin-2-one Derivatives via Cascade Double Nucleophilic Substitution
This research was funded by the Ministry of Science, Technological Development and Innovation, Republic of Serbia through Grant Agreement with University of Belgrade-Faculty of Pharmacy No: 451-03-47/2023-01/ 200161.
Abstract
A cascade, metal-promoted transformation utilizing chloro allenylamide, primary amine, and aryl iodide afforded piperizinones in good yields. Under the optimized conditions the cascade is performed as a one-pot process allowing the formation of three bonds. The synthetic route, controlled by the reaction rates of several processes involved, introduces two points of diversity and is well suited for combinatorial synthesis or related technologies.
Key words
piperizinones - cyclization reactions - allenes - nucleophilic substitution - combinatorial synthesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2201-9951.
- Supporting Information
Publication History
Received: 25 August 2023
Accepted after revision: 31 October 2023
Accepted Manuscript online:
31 October 2023
Article published online:
29 November 2023
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