Novel Synthesis of Pyrido[2,3-b]quinoxaline-3-carboxylate Derivatives via One-Pot Buchwald Amination–Cyclization

Majdi Hajri; Omar Khoumeri; Raoudha Abderrahim; Thierry Terme; Patrice Vanelle

doi:10.1055/a-2183-0324

Synthesis, Table of Contents

Synthesis 2024; 56(01): 187-192
DOI: 10.1055/a-2183-0324

paper

Novel Synthesis of Pyrido[2,3-b]quinoxaline-3-carboxylate Derivatives via One-Pot Buchwald Amination–Cyclization

Majdi Hajri

^aLaboratory of Physics of Lamellar Materials and Hybrids Nanomaterials, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna 7021, Bizerte, Tunisia

,

Omar Khoumeri

^bLaboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, CNRS, UMR 7273, Marseille, France

,

Raoudha Abderrahim

^aLaboratory of Physics of Lamellar Materials and Hybrids Nanomaterials, Faculty of Sciences of Bizerte, University of Carthage, Zarzouna 7021, Bizerte, Tunisia

,

Thierry Terme

^bLaboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, CNRS, UMR 7273, Marseille, France

,

Patrice Vanelle∗

^bLaboratoire de Pharmaco-Chimie Radicalaire, Institut de Chimie Radicalaire ICR, Aix-Marseille Université, CNRS, UMR 7273, Marseille, France

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Abstract

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Abstract

A novel series of pyrido[2,3-b]quinoxaline-3-carboxylate derivatives was synthesized in short reaction times and in moderate to good yields by using a palladium catalyst in a one-pot Buchwald amination/cyclization reaction.

Key words

quinoxalines - nucleophilic substitutions - malonic esters - Buchwald amination/cyclization - palladium catalysis - pyrido[2,3-b]quinoxaline-3-carboxylates

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References

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