Photocatalytic 1,4-Addition of Aromatic Aldehydes or Ketones via Umpoled Carbinol Anions

Abstract

A 1,4-addition reaction of aromatic aldehydes or ketones to electron-deficient olefins was achieved under photocatalytic conditions. In the reaction, an umpoled carbinol anion generated in situ through two successive one-electron reductions of the carbonyl compound reacted nucleophilically with the electron-deficient olefin. Various electron-deficient aromatic aldehydes and ketones successfully underwent the reaction to afford the corresponding γ-functionalized alcohols.

Key words

1,4-addition reaction - carbinol anions - umpolung - photocatalysis - iridium catalysis - alcohols

Publikationsverlauf

Eingereicht: 02. Juni 2023

Angenommen nach Revision: 04. Juli 2023

Accepted Manuscript online:
04. Juli 2023

Artikel online veröffentlicht:
14. August 2023

• References and Notes


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