Synthesis of Quinoline and Quinolin-2(1H)-one Derivatives via Nickel Boride Promoted Reductive Cyclization

Abstract

A mild and efficient approach for the synthesis of diversely substituted quinoline and quinolin-2-one derivatives is disclosed. In situ generated nickel boride proved to be an effective promoter of the reductive cyclization reaction. Broad substrate scope, mild reaction conditions, consistent yield, and a wide range of functional group tolerance are the other notable features of the newly discovered reaction. A large number of quinoline and quinolin-2-one derivatives may be prepared from milligram to multigram scale employing this intramolecular reductive cyclization protocol.

Keywords

quinolines - quinolin-2(1H)-ones - nickel boride - sodium borohydride - reductive cyclization

Publication History

Received: 15 March 2023

Accepted after revision: 22 June 2023

Accepted Manuscript online:
22 June 2023

Article published online:
07 August 2023

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