Efficient α-Arylation of α-Fluoro-α-nitrosulfonylmethanes Employing Diaryliodonium Salts

Abstract

Reported herein is an efficient α-arylation of α-fluoro-α-nitro­sulfonylmethanes using diaryliodonium salts. A wide range of α-fluoronitrosulfonylmethane substrates underwent α-arylation smoothly to produce the corresponding adducts bearing a fully substituted fluorocarbon center in good to excellent yields. The protocol was subsequently shown viable for the α-arylation of α-cyano-α-fluorosulfonylmethane derivatives yielding highly valuable cyano building blocks.

Key words

α-fluoro-α-nitrosulfonylmethanes - diaryliodonium salts - α-arylation - α-fluoro(phenylsulfonyl)acetonitriles - metal-free

Publikationsverlauf

Eingereicht: 28. Juni 2022

Angenommen nach Revision: 12. Juni 2023

Accepted Manuscript online:
12. Juni 2023

Artikel online veröffentlicht:
17. Juli 2023

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