A practical access to cyclopropylamines from the corresponding amides is disclosed,
according to an electro-induced Hofmann rearrangement. In an undivided cell under
galvanostatic conditions, a panel of cyclopropyl amides was readily converted into
the corresponding amines (17 examples, 23% to 94% yield). This reaction allowed an
easy access to the versatile cyclopropylamines and is complementary to the existing
methods.
Key words
cyclopropanes - electrochemistry - Hofmann rearrangement - synthetic method