Research Advances in Electrochemical Synthesis of Spirocyclic Skeleton Compounds

Qian Wang; Han-Fu Liu; Sai-Yan Ren; Mu-Xue He; Ying-Ming Pan

doi:10.1055/a-2019-0399

Synthesis, Table of Contents

Synthesis 2023; 55(18): 2873-2895
DOI: 10.1055/a-2019-0399

short review

Special Issue Electrochemical Organic Synthesis

Research Advances in Electrochemical Synthesis of Spirocyclic Skeleton Compounds

Qian Wang

^aGuangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health of Guilin Medical University, 1 Zhiyuan Road, Guilin 541199, P. R. of China

^bState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, 15 Yucai Road, Guilin 541004, P. R. of China

,

Han-Fu Liu

^bState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, 15 Yucai Road, Guilin 541004, P. R. of China

,

Sai-Yan Ren

^bState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, 15 Yucai Road, Guilin 541004, P. R. of China

,

Mu-Xue He ∗

^aGuangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health of Guilin Medical University, 1 Zhiyuan Road, Guilin 541199, P. R. of China

,

Ying-Ming Pan∗

^bState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, 15 Yucai Road, Guilin 541004, P. R. of China

› Author Affiliations

Abstract

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Abstract

Spirocyclic compounds have attracted the interest of synthetic chemists because of their unique ring systems and utility in drug discovery. Many natural compounds containing spirocyclic moieties in their skeleton are effective pharmaceuticals. For many redox processes, electroorganic synthesis is considered an environmentally friendly method, since the use of reagents with significant toxicity is replaced by electric current, so the amount of waste is often greatly reduced. Therefore, this review summarizes the construction of compounds with a spirocyclic skeleton via electrochemical synthesis strategies since 2000.

1 Introduction

2 Electrochemically Mediated Synthesis of Spirocyclopropanes

3 Electrochemically Mediated Synthesis of Spirooxindoles

4 Electrochemically Mediated Synthesis of Spirodienones

5 Electrochemically Mediated Synthesis of Other Heterospirocycles

6 Conclusion

Key words

electrochemical synthesis - spirocyclic skeleton - spirocyclopropane - spirooxindole - spirodienone

Full Text

References

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