Ruthenium-Catalyzed Regioselective Synthesis of C3-Alkylated Indoles Following Transfer Hydrogenation or Borrowing Hydrogen Strategy

Xia Chen; Xiao-Yu Zhou

doi:10.1055/a-2003-3207

Synthesis, Table of Contents

Synthesis 2023; 55(09): 1460-1466
DOI: 10.1055/a-2003-3207

paper

Ruthenium-Catalyzed Regioselective Synthesis of C3-Alkylated Indoles Following Transfer Hydrogenation or Borrowing Hydrogen Strategy

Xia Chen

^aSchool of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui 553004, P. R. of China

^bGuizhou Key Laboratory of Coal Clean Utilization, Liupanshui 553004, P. R. of China

,

Xiao-Yu Zhou∗

^aSchool of Chemistry and Materials Engineering, Liupanshui Normal University, Liupanshui 553004, P. R. of China

^bGuizhou Key Laboratory of Coal Clean Utilization, Liupanshui 553004, P. R. of China

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Abstract

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Abstract

By employing either borrowing hydrogen or transfer hydrogenation strategy, two straightforward [Ru(p-cymene)Cl₂]₂-catalyzed methods for regioselective synthesis of C3-alkylated indoles have been developed, utilizing alcohols as H atom donors or alkylating agents. The developed catalytic system could accommodate a broad substrate scope including primary/secondary aliphatic alcohols and substituted indoles, and in most cases providing good yields. Notable features of the developed system include high-activity, easy operation, and air atmosphere.

Key words

transfer hydrogenation - borrowing hydrogen - alkylation - indoles - alcohols

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References

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