Synlett 2023; 34(03): 283-287
DOI: 10.1055/a-1970-8386
letter

An Efficient Enantioselective Total Synthesis of Atorvastatin ­Calcium

Naresh Vempala
a   Aragen Life Sciences, Number 12, Plot No 28 A, IDA, Nacharam, Hyderabad, Telangana 500076, India
b   Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, Telangana 500085, India
,
Anireddy Jaya Shree
b   Centre for Chemical Sciences and Technology, Institute of Science and Technology, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, Telangana 500085, India
,
Srikanth Reddy Narra
a   Aragen Life Sciences, Number 12, Plot No 28 A, IDA, Nacharam, Hyderabad, Telangana 500076, India
,
Somnath Dasgupta
a   Aragen Life Sciences, Number 12, Plot No 28 A, IDA, Nacharam, Hyderabad, Telangana 500076, India
› Author Affiliations


Abstract

A concise and efficient asymmetric synthesis of tert-butyl [(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate is presented. This key chiral-chain precursor of atorvastatin was synthesized from a commercially available inexpensive starting material, and was converted into atorvastatin calcium. The synthesis has the potential for scale up, and could be used to produce atorvastatin calcium on an industrial scale.

Supporting Information



Publication History

Received: 24 September 2022

Accepted after revision: 02 November 2022

Accepted Manuscript online:
02 November 2022

Article published online:
25 November 2022

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