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Synthesis 2023; 55(05): 837-845
DOI: 10.1055/a-1961-8013
DOI: 10.1055/a-1961-8013
paper
Development, Synthesis, and in silico Investigations of Novel Acyclic Allyl Fluoride Derivatives
V.S. thanks Department of Science and Technology for DST-Inspire Faculty grant (DST/INSPIRE/04/2017/002529).
Abstract
A one step electrophilic fluorination of alkenes is reported, which furnishes the products in a highly regioselective manner via allylic rearrangement. The reaction proceeds efficiently under mild conditions with the use of trisubstituted alkenes as olefin partner and Selectfluor as an electrophilic fluorinating agent without the need of any transition metal catalyst or pre-functionalized substrates. Virtual screening of the newly synthesized compounds shows their potential application as herbicides by inhibiting protoporphyrinogen oxidase (PPO) enzyme.
Key words
fluorination - metal-free - Selectfluor - organic synthesis - molecular docking - herbicidesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1961-8013.
- Supporting Information
Publication History
Received: 24 June 2022
Accepted after revision: 17 October 2022
Accepted Manuscript online:
17 October 2022
Article published online:
23 November 2022
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