Synlett
DOI: 10.1055/a-1941-2205
synpacts

Improvements in Efficiency and Selectivity for C–F Bond Halogen-Exchange Reactions by Using Boron Reagents

Andrej Ćorković
a   University of Iowa, Chemistry Building, Iowa City, IA 52246, USA
,
Andreas Dorian
b   University of Alberta, 11227 Saskatchewan Drive, Edmonton, AB T6G-2G2, Canada
,
a   University of Iowa, Chemistry Building, Iowa City, IA 52246, USA
› Author Affiliations


Abstract

The use of boron Lewis acids as instigators of bond cleavage offers a number of synthetic possibilities. A unique feature of this class of reagents is the ability to functionalize otherwise inert C–F bonds. We summarize notable developments in C–F bond halogen exchange using Lewis acidic boron reagents and we conclude by featuring our group’s advances in activating CF3 groups by using boron trihalides.

1 Introduction

2 Boron-Mediated Halogen Exchange

3 Mono-Selective C–F Activation

4 Conclusions



Publication History

Received: 16 August 2022

Accepted after revision: 12 September 2022

Accepted Manuscript online:
12 September 2022

Article published online:
25 November 2022

© 2022. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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