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DOI: 10.1055/a-1932-8145
CAR-T-Zell-Therapie – personalisierte zelluläre Immuntherapie im Jahr 2022
CAR-T cell therapy – personalized cellular immunotherapy in 2022
Chimäre Antigen-Rezeptor-T-Zellen (CAR-T-Zellen) sind genetisch modifizierte autologe oder allogene T-Lymphozyten, die sich gegen spezifische Antigene richten und z. B. zur Bekämpfung von Tumorzellen eingesetzt werden können. Die Zulassungsstudien zeigen eine hohe Ansprech- und Remissionsrate bei massiv vorbehandelten Patient*innen mit aggressiven B-Zell-Lymphomen, akuter lymphoblastischer Leukämie oder Multiplem Myelom. Der Beitrag stellt die Zulassungsindikationen, die klinische Durchführung und das Management der Nebenwirkungen der CAR-Zell-Therapie vor.
Abstract
Chimeric antigen receptor T cells (CAR T cells) are genetically modified autologous or allogeneic T lymphocytes that target specific antigens and can be used to combat tumor cells. The approval studies show a high response and remission rate in heavily pretreated patients with aggressive B-cell lymphoma, acute lymphoblastic leukemia or multiple myeloma. The article presents the indications for approval, the clinical implementation and the management of side effects of CAR cell therapy.
Schlüsselwörter
chimäre Antigen-Rezeptor-T-Zellen - CAR-T-Zellen - Zulassungsstudien - Real-World DatenPublikationsverlauf
Artikel online veröffentlicht:
16. November 2022
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Georg Thieme Verlag KG
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