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Synlett 2022; 33(19): 1913-1916
DOI: 10.1055/a-1921-0928
DOI: 10.1055/a-1921-0928
letter
α-Metalated Isocyanides Toward a Tangible Reagent Space
Authors
The research project (to C.G.N) was supported by the Hellenic Foundation for Research and Innovation (H.F.R.I.) under the "2nd Call for H.F.R.I. Research Projects to support Post-Doctoral Researchers” (Project Number: 0911) and by the University of Crete (UoC, ELKE).
Dedicated to Ulrich Schöllkopf, the pioneer of a-metalated isocyanide chemistry
Abstract
α-Metalated isocyanides are a versatile class of compounds that can easily be employed in various transformations, affording tangible libraries for screening campaigns. We report the ring-opening reactions of cyclic anhydrides and lactones with three different metalated isocyanides that readily give 4,5-disubstituted oxazoles, including useful drug-like synthetic intermediates with two functional groups as handles for further modifications.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1921-0928.
- Supporting Information (PDF)
Publication History
Received: 20 June 2022
Accepted after revision: 08 August 2022
Accepted Manuscript online:
08 August 2022
Article published online:
09 September 2022
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