Recent Advances in Transition-Metal-Catalyzed Cross-Coupling Reactions of gem-Difluorinated Cyclopropanes

Dedicated to Professor Jianbo Wang on the occasion of his 60^th birthday

Abstract

As a special class of cyclopropanes, gem-difluorinated cyclopropanes have many fascinating properties as a result of the gem-difluoro substitution; thus, their reactions have received much attention from the synthetic chemistry community. Recently, gem-difluorinated cyclopropanes have gradually emerged as a type of novel and unique fluorinated allylic synthon in cross-coupling reactions for the synthesis of monofluoroalkenes. Herein, we briefly summarize recent advances in transition-metal-catalyzed reactions of gem-difluorinated cyclopropanes.

1 Introduction

2 Palladium-Catalyzed Reactions with Linear Selectivity

3 Palladium-Catalyzed Reactions with Branched Selectivity

4 Other Metal-Catalyzed Reactions

5 Conclusions

Key words

gem-difluorinated cyclopropanes - monofluoroalkenes - transition-metal catalysis - allylation - C–C activation - β-fluorine elimination

Publication History

Received: 24 June 2022

Accepted after revision: 28 July 2022

Accepted Manuscript online:
28 July 2022

Article published online:
21 September 2022

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