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Synthesis 2022; 54(20): 4495-4502
DOI: 10.1055/a-1878-8084
DOI: 10.1055/a-1878-8084
paper
Construction of Quaternary Allylic Amino Acid Derivatives through Palladium-Catalyzed Allylic Alkylation Reaction of Azlactones with Vinyl Aziridine
We are grateful for the financial support from Youth Foundation of Henan Scientific Committee (No. 222300420249), Foundation of Henan Education Committee (No. 21A150039) and Doctoral Research Start-up Fund project of Nanyang Institute of Technology (No. NGBJ-2021-03).
Abstract
A highly efficient Pd-catalyzed allylic alkylation reaction of azlactones with vinyl aziridine has been achieved for the first time to access functionalized quaternary allylic amino acid derivatives (17 examples, up to 89% yield and 80% ee). Moreover, the broad scope and easy transformations of the products reinforce the value of this approach, which can enrich the chemistry of quaternary allylic amino acid derivatives.
Key words
allylic alkylation - quaternary allylic amino acid derivatives - Pd-catalyzed - vinyl aziridine - azlactonesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1878-8084.
- Supporting Information
Publication History
Received: 15 April 2022
Accepted after revision: 20 June 2022
Accepted Manuscript online:
20 June 2022
Article published online:
27 July 2022
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