The biological activity of natural products YM-254890 (YM) and FR900359 (FR) has led
to significant interest in both their synthesis and the construction of more simplified
analogs. While the simplified analogs lose much of the potency of the natural products,
they are of interest in their own right, and their synthesis has revealed synthetic
barriers to the family of molecules that need to be addressed if a scalable synthesis
of YM and FR analogs is to be constructed. In the work described here, a synthetic
route to simplified analogs of YM is examined and strategies for circumventing some
of the challenges inherent to constructing the molecules are forwarded.
Key words
YM-254890 - FR900359 - analogs - scalable synthesis
