Iodine-Promoted N-Acylation of Amines with Hydrazide: An Efficient Metal-Free Amidation

Abstract

An efficient protocol for the amidation of hydrazide with amine has been developed by utilizing I₂ as an oxidant under metal- and base-free conditions at room temperature. N-Acylation products of amines were obtained in good to excellent yields without using toxic reagents. This method is operationally straightforward and tolerates aliphatic/aromatic and primary/secondary amines with different hydrazides.

Key words

amidation - metal-free - hydrazide - oxidant - acylation

Publication History

Received: 10 March 2022

Accepted after revision: 28 April 2022

Accepted Manuscript online:
28 April 2022

Article published online:
08 June 2022

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