Recurrent Corneal and Conjunctival Dysplasia in an Immunocompromised Patient – The Interesting Case

Background

Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia, which is a precancerous lesion and part of the spectrum of diseases called ocular surface squamous neoplasia (OSSN). The lesion usually develops at the limbal region of the interpalpebral conjunctiva. Main risk factors include ultraviolet light exposure, human papillomavirus (HPV) infection, and immunosuppression (HIV/AIDS). Surgical excision, usually with adjunctive cryotherapy, has been the traditional therapy for OSSN [1]. Because of a high recurrence rate after surgical excision [2], topical chemotherapy including mitomycin-C (MMC), 5-fluorouracil (5-FU), and interferon (IFN) has been used extensively [3], [4], [5]. Here, we report a case of recurrent conjunctival and corneal intraepithelial neoplasia.

Publication History

Received: 14 September 2021

Accepted: 27 February 2022

Article published online:
26 April 2022

• References

• 1 Fraunfelder FT, Wingfield D. Therapy of intraepithelial epitheliomas and squamous cell carcinoma of the limbus. Trans Am Ophthalmol Soc 1980; 78: 290-300
• 2 Yang J, Foster CS. Squamous cell carcinoma of the conjunctiva. Int Ophthalmol Clin 1997; 37: 73-85
• 3 Gupta A, Muecke J. Treatment of ocular surface squamous neoplasia with Mitomycin C. Br J Ophthalmol 2010; 94: 555-558
• 4 Frucht-Pery J, Sugar J, Sutphin JE. et al. Mitomycin C treatment for conjunctival-corneal intraepithelial neoplasia: a multicenter experience. Ophthalmology 1997; 104: 2085-2093
• 5 Frucht-Pery J, Rozenman Y, Peʼer J. Topical mitomycin-c for partially excised conjunctival squamous cell carcinoma. Ophthalmology 2002; 109: 548-552
• 6 Tabin G, Levin S, Snibson G. et al. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology 1997; 104: 485-492
• 7 Shields CL, Naseripour M, Shields JA. Topical mitomycin C for extensive, recurrent conjunctival-corneal squamous cell carcinoma. Am J Ophthalmol 2002; 133: 601-606