Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-Light-Mediated Cyclization of Acryloylbenzamides with Alkylboronic Acids, Arylsulfonyl Hydrazides and Oxime Esters

Jiahui Fu; Xingxing Cai; Yihuo Liu; Jinghua Li; Dongping Cheng; Xiaoliang Xu

doi:10.1055/a-1734-9782

Synthesis, Table of Contents

Synthesis 2022; 54(11): 2707-2723
DOI: 10.1055/a-1734-9782

paper

Synthesis of Isoquinoline-1,3(2H,4H)-diones by Visible-Light-Mediated Cyclization of Acryloylbenzamides with Alkylboronic Acids, Arylsulfonyl Hydrazides and Oxime Esters

Jiahui Fu

^aCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

,

Xingxing Cai

^aCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

,

Yihuo Liu

^aCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

,

Jinghua Li

^bCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

,

Dongping Cheng∗

^bCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

,

Xiaoliang Xu∗

^aCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

› Author Affiliations

Abstract

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Abstract

An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkylboronic acids, arylsulfonyl hydrazides and oxime esters has been developed. The reaction proceeds via radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.

Key words

acryloylbenzamides - isoquinolinediones - addition/cyclization reaction - visible light - photocatalysis

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References

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