Synthesis of Rigid Rod, Trigonal, and Tetrahedral Nucleobase-Terminated Molecules

Xiao-Yang Jin; Chuan-Shuo Wu; An-Di Liu; Li Liu; Liang Cheng

doi:10.1055/a-1695-0820

Synthesis, Table of Contents

Synthesis 2022; 54(06): 1643-1651
DOI: 10.1055/a-1695-0820

paper

Synthesis of Rigid Rod, Trigonal, and Tetrahedral Nucleobase-Terminated Molecules

Xiao-Yang Jin

^aBeijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

,

Chuan-Shuo Wu

^aBeijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

,

An-Di Liu

^aBeijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

,

Li Liu

^aBeijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

,

Liang Cheng ∗

^aBeijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. of China

^bUniversity of Chinese Academy of Sciences, Beijing 100049, P. R. of China

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Abstract

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Dedicated to Professor Dong Wang on the occasion of his 80th birthday.

Abstract

An efficient fragment splicing method for the construction of multiple nucleobase-terminated monomers has been developed. Conformationally fixed rod, trigonal planar and tetrahedral thymine and adenine structures were generated in moderate to good yields, which will serve as inspiring examples for exploration of nucleobases as natural hydrogen-bond components in supramolecular chemistry.

Key words

nucleobases - cross-coupling - alkynes - arylation - dendrimers

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References

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