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Synlett 2022; 33(03): 283-287
DOI: 10.1055/a-1679-7225
DOI: 10.1055/a-1679-7225
letter
Iron-Catalyzed Synthesis of Pyridines from α,β-Unsaturated Ketoxime Acetates and N-Acetyl Enamides
We gratefully acknowledge the National Natural Science Foundation of China (22078150), the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (XTE1826) and the Natural Science Research Projects of Jiangsu Higher Education (19KJB150027) for their financial support.
Abstract
A new method of FeCl2-catalyzed [4+2] annulation of α,β-unsaturated ketoxime acetates with N-acetyl enamides in batch and flow is reported. The current strategy features low-cost catalytic system, use of electron-rich olefins, operational simplicity, and broad substrate scope, thus providing a facile and efficient access to substituted pyridines in moderate to good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1679-7225.
- Supporting Information
Publikationsverlauf
Eingereicht: 18. Oktober 2021
Angenommen: 27. Oktober 2021
Accepted Manuscript online:
27. Oktober 2021
Artikel online veröffentlicht:
22. November 2021
© 2021. Thieme. All rights reserved
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