A Metal-Free β-Stereoselective Synthesis of 2-Deoxy-C-arylglycosides: Synthesis of 5-Aza Analogues of Aquayamycin

Abstract

A convenient protocol for the β-stereoselective synthesis of 2-deoxy-C-arylglycosides has been developed. This reaction takes place in one step by using I₂/Et₃SiH to activate a glycosyl acetate to generate a glycosyl iodide intermediate in situ, which is captured by a naphthol; this is followed by a Fries-like O-to-C glycoside rearrangement to afford a β-C-aryl glycoside selectively. The approach is applicable to a wide range of naphthol moieties, and its utility was demonstrated in syntheses of 5-aza analogues of aquayamycin.

Key words

glycosylation - deoxyarylglycosides - glycosyl iodides - metal-free synthesis - aquayamycin

Publication History

Received: 21 July 2021

Accepted after revision: 15 October 2021

Accepted Manuscript online:
15 October 2021

Article published online:
11 November 2021

• References and Notes

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