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Synthesis 2022; 54(03): 683-688
DOI: 10.1055/a-1652-3714
DOI: 10.1055/a-1652-3714
paper
Total Synthesis of Thiocladospolide A and Its C2-Epimer
P.S. is grateful to the Council of Scientific and Industrial Research (CSIR), New Delhi, India for a fellowship.
Abstract
The first total synthesis of the recently isolated natural product thiocladospolide A, along with its C2-epimer, is achieved in nine straightforward linear steps and 12% overall yield. The key feature of the synthesis is the construction of the macrocyclic ring via a late-stage ring-closing metathesis reaction followed by alkene reduction.
Key words
total synthesis - macrolide - thiocladospolide A - sulfa-Michael addition - ring closing metathesisSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1652-3714.
- Supporting Information
Publikationsverlauf
Eingereicht: 24. August 2021
Angenommen nach Revision: 23. September 2021
Accepted Manuscript online:
23. September 2021
Artikel online veröffentlicht:
03. November 2021
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