A mild and facile synthetic method via convergent assembly of two reactive intermediates
generated in situ has been developed. This method provides an efficient way to construct
six- and seven-membered N-heterocycles containing a biaryl linkage. This reaction features a gem-difunctionalization process of diazo compounds with cyclic hemiaminals, delivering
α-hydroxyl-β-amino ester derivatives with a tertiary carbon center through a formal
C–O bond-insertion transformation.
Key words
metal carbene - cyclic hemiaminals - α-hydroxyl-β-amino esters -
N-heterocycles - atom economy