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Synthesis 2021; 53(20): 3827-3835
DOI: 10.1055/a-1516-9893
paper

New Phosphorylating Agents for the Synthesis of Phosphatidyl­ethanolamines

Kouta Tsubaki
,
Tomoki Yamanaka
,
Takuya Hisamitsu
,
Hirokazu Shimooka
,
Mitsuru Kitamura
,
Tatsuo Okauchi  ∗
We gratefully acknowledge financial support for this research from the Institute of Rheological Functions of Food.
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Abstract

The preparation of three novel phosphorylating agents and their application toward the synthesis of phosphatidylethanolamines is described. These reagents are stable to air and moisture, and phosphorylate glycerols in good yield. The experimental procedures using these phosphorylating agents are simple. Moreover, the appropriate reagent can be selected based on the desired functional groups of the targeted phosphatidylethanolamine.

Key words

phosphorylation - phosphatidylethanolamines - transesterification - glycerophospholipids - dialkyl 2,2,2-trifluoroethyl phosphates

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-1516-9893.
  • Supporting Information


Publication History

Received: 11 May 2021

Accepted after revision: 25 May 2021

Accepted Manuscript online:
25 May 2021

Article published online:
22 June 2021

© 2021. Thieme. All rights reserved

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