Synthesis 2021; 53(10): 1828-1832
DOI: 10.1055/a-1441-3236
paper

A Practical Procedure for Regioselective Bromination of Anilines

Yusuke Takahashi
,
Masahiko Seki


Abstract

A highly practical procedure for the preparation of bromoanilines by using copper-catalyzed oxidative bromination has been developed. Treatment of free anilines with readily available NaBr and Na2S2O8 in the presence of a catalytic amount of CuSO4·5H2O enabled regioselective bromination.

Supporting Information



Publication History

Received: 01 March 2021

Accepted after revision: 16 March 2021

Publication Date:
16 March 2021 (online)

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
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