Alkyl Halides as Substrates for Photocatalytic Minisci-Type C–H Alkylation of Hetarenes

Jędrzej Predygier; Joanna Szczepanik; Maciej Giedyk

doi:10.1055/a-1404-2763

Synlett, Table of Contents

Synlett 2022; 33(02): 103-108
DOI: 10.1055/a-1404-2763

Synpacts

EuCheMS Organic Division Young Investigator Workshop

Alkyl Halides as Substrates for Photocatalytic Minisci-Type C–H Alkylation of Hetarenes

Jędrzej Predygier‡

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

^bFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland

,

Joanna Szczepanik‡

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

^cFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland

,

Maciej Giedyk ∗

^aInstitute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland

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Abstract

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Dedicated to Professor Daniel Gryko on the occasion of his 50^th birthday

Abstract

Alkyl halides are readily available starting materials for various synthetic transformations, including Minisci-type C–H functionalizations of hetarenes. The existing methods, however, often require harsh reaction conditions, such as the use of acids, sacrificial electron donors, or radical precursors in excess amounts. Here, we outline recent developments in this field and we highlight our group̓s efforts to achieve fully catalytic photoredox Minisci-type alkylations supported by noncovalent interactions under mild aqueous conditions.

Key words

C–H functionalization - Minisci reaction - alkyl bromides - hetarenes - photoredox catalysis - alkylation

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References

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