Klin Monbl Augenheilkd 2021; 238(04): 361-364
DOI: 10.1055/a-1384-1159
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Proton Therapy of a Conjunctival Carcinoma in the Anophthalmic Socket, 41 Years after Enucleation for a Sporadic Retinoblastoma. A Case Report and Review of the Literature

Protonentherapie für Bindehautkarzinom in der anophthalmischen Höhle 41 Jahre nach Enukleation wegen sporadischen Retinoblastoms
Alexandre Moulin
1  Jules-Gonin Eye Hospital, Lausanne University, FAA, Switzerland
Alessia Pica
2  Ophthalmology, Paul Scherrer Institut, Villigen, Switzerland
Francis Munier
1  Jules-Gonin Eye Hospital, Lausanne University, FAA, Switzerland
Ann Schalenbourg
1  Jules-Gonin Eye Hospital, Lausanne University, FAA, Switzerland
Antoine Nobile
3  Pathology, Promed SA, Marly, Switzerland
Aliaksandr Asana
4  Otorhinolaryngology, Fribourg Hospitals, Fribourg, Switzerland
Christoforos Astaras
5  Oncology, Fribourg Hospitals, Fribourg, Switzerland
Mehrad Hamedani
1  Jules-Gonin Eye Hospital, Lausanne University, FAA, Switzerland
› Author Affiliations


We document here an aggressive carcinoma arising in the conjunctiva of an anophthalmic socket, 41 years after enucleation for a sporadic, non-hereditary unilateral retinoblastoma. This tumor was treated for the first time with proton beam irradiation of the orbit. Investigations revealed an extensive metastatic spread to the loco-regional lymph nodes, requiring complementary parotidectomy, chemotherapy, and radiation therapy.

The incidence of conjunctival carcinoma arising in the bulbar conjunctiva peaks in Africa (3.4/100 000/year) and has been linked to factors contributing to its development, such as UV light exposure, as well as HIV or HPV infections [1]. On the contrary, carcinomas arising in the conjunctiva of anophthalmic sockets are extremely rare and, so far, only 23 cases have been documented, usually occurring a long time after enucleation. We document here the clinicopathological findings of a conjunctival carcinoma identified in the anophthalmic socket of a patient enucleated 41 years ago for a sporadic, unilateral retinoblastoma.

Publication History

Received: 25 September 2020

Accepted: 25 January 2021

Publication Date:
30 April 2021 (online)

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