Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides

Abstract

The use of carbon dioxide as a C1 chemical feedstock remains an active field of research. Here we showcase the use of milled dry ice as a method to promote the availability of CO₂ in a reaction solution, permitting practical synthesis of arylcarboxylic acids. Notably, the use of milled dry ice produces marked increases in yields relative to those obtained with gaseous CO₂, as previously reported in the literature.

Key words

carboxylation - carbon dioxide - C1 source - dry ice - arylcarboxylic acids

Publication History

Received: 18 December 2020

Accepted after revision: 04 February 2021

Accepted Manuscript online:
04 February 2021

Article published online:
19 February 2021

• References and Notes

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