Synlett 2021; 32(15): 1494-1512
DOI: 10.1055/a-1349-3543
cluster
Modern Nickel-Catalyzed Reactions

Biaryl Construction Based on Nickel-Catalyzed C–O Bond Activation

Haiyan Diao
a   School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, 201418, P. R. of China
,
Zhangjie Shi
b   Department of Chemistry, Fudan University, Shanghai, 200438, P. R. of China
,
Feng Liu
a   School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai, 201418, P. R. of China
b   Department of Chemistry, Fudan University, Shanghai, 200438, P. R. of China
› Author Affiliations
This work was supported by the National Natural Science Foundation of China (NSFC) (21988101, 21761132027, 22071029, U19B6002), the Science and Technology Commission of Shanghai Municipality (19XD1400800, 18JC1411300), the Shanghai Municipal Education Commission (2017-01-07-00-07-E00058), the Key-Area Research and Development Program of Guangdong Province (2020B010188001), and the Shanghai Gaofeng & Gaoyuan Project for University Academic Program Development.


Abstract

Nickel-catalyzed carbon–oxygen bond activation is one of the most powerful strategies for the direct construction of various biaryl compounds. Under nickel catalysis, efficiently produced and naturally abundant arenol-based electrophiles can be activated and coupled with different aryl nucleophiles, including nucleophiles containing magnesium, zinc, boron, etc., to produce biaryl structural units. This Account summarizes recent progress on biaryl synthesis via nickel-catalyzed C–O bond activation.

1 Introduction

2 Coupling of Arenols and Arenol Derivatives with Aryl Magnesium Reagents

3 Coupling of Arenols and Arenol Derivatives with Aryl Zinc Reagents

4 Coupling of Arenols and Arenol Derivatives with Aryl Boron Reagents

5 Others

6 Conclusion



Publication History

Received: 01 November 2020

Accepted after revision: 11 January 2021

Accepted Manuscript online:
11 January 2021

Article published online:
28 January 2021

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