Synthesis 2021; 53(10): 1833-1841
DOI: 10.1055/a-1337-4684
paper

Controllable Lewis Base Catalyzed Michael Addition of α-Amino­nitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

Ze-Ying He
a  Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China
b  Zhuhai College of Jilin University, Jilin University, Zhuhai 519041, P. R. of China
,
Ho-Chol Jang
a  Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China
,
Le-Sheng Teng
c  College of Life Sciences, Jilin University, Changchun 130012, P. R. of China
,
Zhong-Lin Wei
a  Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China
,
Wei-Wei Liao
a  Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China
› Author Affiliations
National Natural Science Foundation of China (21772063).


Abstract

A novel protocol for the synthesis of functionalized γ-amino acid esters and γ-lactams through a controllable Lewis base catalyzed Michael addition of α-aminonitriles to simple activated alkenes has been developed. The scope, versatility, and efficiency of the process were demonstrated.

Supporting Information



Publication History

Received: 26 November 2020

Accepted after revision: 15 December 2020

Publication Date:
15 December 2020 (online)

© 2020. Thieme. All rights reserved

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