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Synthesis 2021; 53(13): 2212-2218
DOI: 10.1055/a-1331-7346
DOI: 10.1055/a-1331-7346
paper
Mild and Efficient Copper-Catalyzed Synthesis of Trisubstituted Pyrroles
Authors
The project was supported by the Ministry of Science and Technology (MOST 106-2113-M -018-008, MOST 107-2113-M-018-008, MOST 108-2113-M-018-009). M. Kapoor thanks the Start-up funding from Chitkara University and Chitkara University Research and Innovation Network.
Abstract
A sustainable and time economic approach has been developed for the synthesis of polysubstituted pyrroles using copper iodide as a catalyst. The reaction proceeded through imine formation followed by cyclization with alkyne-Cu intermediate, which was supported by control experiments studies. The newly formed substituted pyrroles were obtained in excellent yields with high regioselectivity under mild conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1331-7346.
- Supporting Information (PDF)
- CIF File (ZIP)
Publication History
Received: 24 September 2020
Accepted after revision: 07 December 2020
Accepted Manuscript online:
07 December 2020
Article published online:
02 March 2021
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