Modular Synthesis of α-Substituted Alkenyl Acetals via Pd-Catalyzed Suzuki Reaction of α-Halide Alkenyl Acetals with Organoboranes
A modular and straightforward synthetic strategy for the preparation of α-substituted alkenyl acetals has been developed. α-Halide alkenyl acetals could react smoothly with (hetero)aryl boronic acids, aryl boronates and alkyl-9-BBN via Pd-catalyzed Suzuki cross-coupling under mild reaction conditions in good to high yields. This protocol features broad substrate scope, good functional group compatibility, and easy scale-up ability.
Received: 04 November 2020
Accepted after revision: 25 November 2020
25 November 2020 (online)
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