Synlett
DOI: 10.1055/a-1322-3916
Letter

Modular Synthesis of α-Substituted Alkenyl Acetals via Pd-Catalyzed Suzuki Reaction of α-Halide Alkenyl Acetals with Organoboranes

Li Zhang
1  Zhejiang Pharmaceutical College, School of Fundamental Science, Ningbo, China (Ringgold ID: RIN92268)
› Author Affiliations

A modular and straightforward synthetic strategy for the preparation of α-substituted alkenyl acetals has been developed. α-Halide alkenyl acetals could react smoothly with (hetero)aryl boronic acids, aryl boronates and alkyl-9-BBN via Pd-catalyzed Suzuki cross-coupling under mild reaction conditions in good to high yields. This protocol features broad substrate scope, good functional group compatibility, and easy scale-up ability.



Publication History

Received: 04 November 2020

Accepted after revision: 25 November 2020

Publication Date:
25 November 2020 (online)

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