Synlett 2021; 32(04): 423-428
DOI: 10.1055/a-1303-5613

Synthetic Study on Acremoxanthone A, Part 2: Model Study on the EFG Xanthone Moiety through a Nitrile Oxide Cycloaddition–SNAr Sequence

Hiroshi Nakakohara
Yoichi Hirano
This work was supported by Grants-in-Aid from the Japan Society for the Promotion of Science (JSPS) (Grant Nos. JP16H06351 and JP18K06548).


Toward a total synthesis of acremoxanthone A, we report a model study on the construction of the EFG ring system. The key steps include (1) an intermolecular 1,3-dipolar cycloaddition of an aryl nitrile oxide with a dienone, and (2) an SNAr reaction for construction of the F ring.

Supporting Information

Publication History

Received: 24 October 2020

Accepted after revision: 04 November 2020

Accepted Manuscript online:
04 November 2020

Article published online:
02 December 2020

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