Klin Monbl Augenheilkd
DOI: 10.1055/a-1252-2910
Klinische Studie

Test-Retest-Reliability of Computer-Based Metamorphopsia Measurement in Macular Diseases

Article in several languages: English | deutsch
Daniela Claessens
1  Gemeinschaftspraxis Augenheilkunde Lindenthal, Köln, Deutschland
Alexander K. Schuster
2  Augenklinik, Universitätsmedizin Mainz, Deutschland
Ronald V. Krüger
3  Development, app4eyes GmbH & Co KG, Düsseldorf, Deutschland
Marian Liegl
4  Humanmedizinische Fakultät, Universität zu Köln, Deutschland
Laila Singh
5  Max-Planck-Institut für Biologie des Alterns, Köln, Deutschland
Bernd Kirchhof
6  Abteilung für Netzhaut- und Glaskörper-Chirurgie, Zentrum für Augenheilkunde, Universität zu Köln, Deutschland
› Author Affiliations


In this study, the test-retest-reliability as one aspect of reliability of metamorphopsia measurements using a computer-based measuring method was determined in patients with macular diseases. Metamorphopsia amplitude, position, and area were quantified using AMD – A Metamorphopsia Detector software (app4eyes GmbH & Co. KG, Germany) in patients with diabetic, myopic, or uveitic macular edema, intermediate or neovascular age-associated macular degeneration, epiretinal membrane, vitelliform maculopathy, Irvine-Gass syndrome, or macular edema due to venous retinal occlusion. The intraclass correlation coefficient (ICC) was calculated in order to determine the repeatability of two repeated measurements and was used as an indicator of the reliability of the measurements. In this study, metamorphopsia measurements were conducted on 36 eyes with macular diseases. Metamorphopsia measurements made using AMD – A Metamorphopsia Detector software were highly reliable and repeatable in patients with maculopathies. The intraclass correlation coefficient of all indices was excellent (0.95 – 0.97). For diseases of the vitreoretinal interface or macular diseases with intra- or subretinal edema, this metamorphopsia measurement represents a supplement for visual function testing in the clinic, as well as in clinical studies.

Publication History

Received: 21 June 2020

Accepted: 31 August 2020

Publication Date:
07 December 2020 (online)

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany