Chronische Pankreatitis und Autoimmunpankreatitis – Ein Update

Die steigende Prävalenz der chronischen Pankreatitis rückt diese Erkrankung immer weiter in den Fokus. Chronische Schmerzen und Komplikationen beeinträchtigen die Lebensqualität und Lebenserwartung der Patienten und stellen eine therapeutische Herausforderung dar. Dieser Beitrag fasst die ätiologischen und diagnostischen Grundlagen zusammen und diskutiert konservative und interventionelle Therapiestrategien.

Abstract

Chronic pancreatitis is a complex chronic inflammatory condition that results in pancreas fibrosis and calcification with subsequent exocrine and endocrine insufficiency. Alcohol and nicotine are the most prevalent risk factors, however, recent studies have increasingly discovered genetic associations that increase the risk to develop chronic pancreatitis. Here, we discuss different etiologies of the disease including autoimmune pancreatitis, and present evidence-based diagnostic and therapeutic approaches. In particular, we highlight the interdisciplinary and interventional management of local complications such as pseudocysts, pancreatic duct stones, biliary duct and pancreatic duct stenosis and persistent pain.

Schlüsselwörter

chronische Pankreatitis - Autoimmunpankreatitis - exokrine Insuffizienz - Endoskopie - Pseudozyste - chronischer Schmerz

Key words

chronic pancreatitis - autoimmune pancreatitis - exocrine insufficiency - endoscopy - pseudocyst - chronic pain

Publication History

Article published online:
16 February 2021

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