Infekt-assoziierte Glomerulonephritiden

Abstract

Glomerulonephritis, secondary to bacterial, or, more rarely, viral or parasitic infections, is called infection-associated. The epidemiology of infection-associated glomerulonephritis has changed in recent decades. For a long time, the classic form has been acute poststreptococcal glomerulonephritis (APGN), but in developed countries its incidence has declined sharply. However, there is an increase in staphylococcal associated glomerulonephritis (SAGN). The clinical manifestations of APGN and SAGN are different: APGN typically presents with a glomerulonephritis after an infectious latency period (post-infectious), while SAGN typically shows an immune complex glomerulonephritis concomitant with infection (para-infectious). SAGN often presents with an occult infections in older patients with multiple comorbidities.

Glomerulonephritiden, die sekundär bei meist bakteriellen, seltener bei viralen oder parasitären Infektionen auftreten, werden als Infekt-assoziiert bezeichnet. Die Epidemiologie hat sich in den letzten Jahrzehnten gewandelt. Der klassische Vertreter war lange Zeit die akute Poststreptokokken-Glomerulonephritis, in westlichen Industrieländern handelt es sich heutzutage zumeist um Staphylokokken-assoziierte Glomerulonephritiden [1].

Schlüsselwörter

Nierenerkrankung - Immunkomplex-Glomerulonephritis - Infekt-assoziierte Glomerulonephritis - Poststreptokokken-Glomerulonephritis - Staphylokokken-assoziierte Glomerulonephritis

Key words

glomerulonephritis - kidney disease - chronic renal insufficiency - immune complex glomerulonephritis - infection associated glomerulonephritis - poststreptococcal glomerulonephritis - staphylococcal associated glomerulonephritis

• Literatur

• 1 Satoskar AA, Parikh SV, Nadasy T. Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis. Nat Rev Nephrol 2019; DOI: 10.1038/s41581-019-0178-8.
• 2 Kimmel M, Kuhlmann U. Glomerulonephritiden. In: Kuhlmann U, Luft FC, Böhler J. et al. Hrsg Nephrologie – Pathophysiologie – Klinik – Praxis. 6.. Aufl. Stuttgart: Thieme; 2015: 70-135
• 3 Nast CC, Rodríguez-Iturbe B. Glomerular diseases associated with infection. In: Feehally J, Floege J, Tonelli M. et al. Hrsg Comprehensive clinical nephrology. 6th . edn. New York: Elsevier; 2019: 664-677
• 4 Delves PJ, Martin SJ, Burton DR. et al. Roitt’s essential immunology. 11th . edn. New York: John Wiley & Sons; 2011
• 5 Nasr SH, Radhakrishnan J, D’Agati VD. Bacterial infection-related glomerulonephritis in adults. Kidney Int 2013; 83: 792-803
• 6 Carapetis JR, Steer AC, Mulholland EK. et al. The global burden of group A streptococcal diseases. Lancet Infect Dis 2005; 5: 685-694
• 7 Rodríguez-Iturbe B, Batsford S. Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet. Kidney Int 2007; 71: 1094-1104
• 8 Nasr SH, Fidler ME, Valeri AM. et al. Postinfectious glomerulonephritis in the elderly. J Am Soc Nephrol 2011; 22: 187-195
• 9 Sethi S, Fervenza FC, Zhang Y. et al. Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement. Kidney Int 2013; 83: 293-299
• 10 DeLeo FR, Otto M, Kreiswirth BN. et al. Community-associated methicillin-resistant Staphylococcus aureus. Lancet 2010; 375: 1557-1568
• 11 Glassock RJ, Alvarado A, Prosek J. et al. Staphylococcus-related glomerulonephritis and poststreptococcal glomerulonephritis: why defining “post” is important in understanding and treating infection-related glomerulonephritis. Am J Kidney Dis 2015; 65: 826-832
• 12 Nasr SH, D’Agati VD. Iga-dominant postinfectious glomerulonephritis: a new twist on an old disease. Nephron Clin Pract 2011; 119: c18-c26
• 13 Satoskar AA, Suleiman S, Ayoub I. et al. Staphylococcus infection-associated GN — spectrum of IgA staining and prevalence of ANCA in a single-center cohort. Clin J Am Soc Nephrol 2017; 12: 39-49
• 14 Langlois V, Lesourd A, Girszyn N. et al. Antineutrophil cytoplasmic antibodies associated with infective endocarditis. Medicine (Baltimore) 2016; 95: e2564
• 15 Kimmel M, Kuhlmann U. Nierenbeteiligung bei Systemerkrankungen. In: Kuhlmann U, Luft FC, Böhler J. et al. Hrsg Nephrologie – Pathophysiologie – Klinik – Praxis. 6.. Auflage Stuttgart: Thieme; 2015: 136-235
• 16 Venkataseshan VS, Lieberman K, Kim DU. et al. Hepatitis-B-associated glomerulonephritis: pathology, pathogenesis, and clinical course. Medicine (Baltimore) 1990; 69: 200
• 17 Sabry AA, Sobh MA, Irving WL. et al. A comprehensive study of the associatin between hepatitis C virus and glomerulopathy. Nephrol Dial Transplant 2002; 17: 239