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Synthesis 2006(5): 860-864
DOI: 10.1055/s-2006-926323
DOI: 10.1055/s-2006-926323
PAPER
© Georg Thieme Verlag Stuttgart · New YorkReusable and Efficient Pd(OAc)2/TBAB/PEG-400 System for Suzuki-Miyaura Cross-Coupling Reaction under Ligand-Free Conditions
Further Information
Received
18 August 2005
Publication Date:
07 February 2006 (online)
Publication History
Publication Date:
07 February 2006 (online)

Abstract
The combination of Pd(OAc)2, TBAB and PEG-400 [poly(ethylene glycol-400)] was introduced as a reusable and efficient system for the Suzuki-Miyaura cross-coupling reaction. In the presence of 0.01 to 3 mol% of Pd(OAc)2, 10 mol% of TBAB, 2 equivalents of K2CO3 and 4 g of PEG-400, a number of aryl halides were coupled with arylboronic acids efficiently to afford moderate to excellent yields of the corresponding products under ligand-free conditions. Moreover, the system can be reused three times without any loss of catalytic activity.
Key words
Pd(OAc)2 - TBAB - PEG-400 - Suzuki-Miyaura cross-coupling reaction - aryl halides - arylboronic acids
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