Valuable Synthetic Building Blocks: Useful 2-Substituted 5-Amino­pyrimidines from a Stable Precursor

Abstract

An efficient large-scale synthesis of 5-aminopyrimidine derivatives is described. The dihexafluorophosphate salt of a vin­amidinium cation important in 5-aminopyrimidine synthesis has been prepared as a stable, easily purified intermediate. It has been used to prepare several 2-functionalized aminopyrimidines, valuable as synthetic building blocks.

heterocycles - pyrimidines - condensation - amidine - vinamidinium

References

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Current address: Laboratoires IDENIX, Rue de la Valsière, Parc Euromédecine, 34090 Montpellier, France.

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