Palladium-Catalyzed Esterification-Hydroarylation Reactions of 2-Alkynylbenzaldehydes with Aryl Iodides in Methanol

Abstract

The reaction of 2-alkynylbenzaldehydes with aryl iodides in the presence of Pd(PPh₃)₄ and K₂CO₃ in refluxing methanol for 24 hours gave the dehydrogenation-addition products, methyl 2-(2,2-disubstituted-vinyl)benzoates in modest yields; together with the cyclization products, 3-methoxy-1-monosubstituted-methylene-3-hydroisobenzofurans in 3-18% yields.

palladium - coupling - esterification-hydroarylation - 2-alkynylbenzaldehydes

References

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