In(OTf)₃-Catalyzed Friedel-Crafts Reaction of Aromatic Compounds with Methyl Trifluoropyruvate in Water

Abstract

In the presence of In(OTf)₃ as a catalyst, aniline derivatives 1a-c, 1e-h and anisole derivatives 2a-c, 2e reacted with methyl trifluoropyruvate 3 in water at room temperature to give the corresponding Friedel-Crafts reaction products 4a-g and 5a-d in good yields, respectively.

Key words

In(OTf)₃ catalyst - Friedel-Crafts reaction - methyl trifluoropyruvate - water - CF₃-substituted compound

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